SUMO Modification: Wrestling with Protein Conformation

Wrestling with heart failure: SUMO-1 to the rescue.

A small ubiquitin-like protein was shown to be beneficial to the failing heart through enhancing sarcoplas-mic reticulum Ca 2+ ATPase 2a (SERCA2a) stability and activity in a large animal model of heart failure. Dysregulation of calcium cycling in cardiomyocytes has been recognized as a major molecular mechanism of heart failure. SERCA2a plays a pivotal role in regulating calcium homeostasis, a...

Wrestling rules in transrepression: as easy as SUMO-1, -2, -3?

A recent study in Molecular Cell uncovered parallel yet distinct SUMOylation pathways that provide insights into molecular mechanisms of transrepression mediated by activated nuclear receptors LXRalpha/beta and PPARgamma, thereby clarifying receptor, signal, and gene specificity of transrepression in inflammatory processes.

Preliminary and incomplete Beliefs, Skills, and Winning: Evidence from Sumo Wrestling

SUMO wrestling with Ras

This review discusses our current understanding of the small ubiquitin-like modifier (SUMO) pathway and how it functionally intersects with Ras signaling in cancer. The Ras family of small GTPases are frequently mutated in cancer. The role of the SUMO pathway in cancer and in Ras signaling is currently not well understood. Recent studies have shown that the SUMO pathway can both regulate Ras/MA...

Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.

Heat shock transcription factor 2 (HSF2) is a transcription factor that regulates heat shock protein gene expression, but the mechanisms regulating the function of this factor are unclear. Here we report that HSF2 is a substrate for modification by the ubiquitin-related protein SUMO-1 and that HSF2 colocalizes in cells with SUMO-1 in nuclear granules. Staining with anti-promyelocytic leukemia a...